It was intended to have Ryan Reynolds play the main character. However, scheduling conflicts with The Hitman's Bodyguard (2017) forced him to take a supporting role instead.

Rebecca Ferguson had originally turned down the part of Dr. Miranda North, British, Quarantine Officer, as she thought she would not live up to the standards of the movie. She expressed her anxiety and fear to the producer, who advised her to talk with Daniel Espinosa whose philosophy and ideas for the film impressed her enough for her to change her mind and eventually take part in the movie.

This was Skydance's first R-rated feature film.

In a TV spot commercial, it was revealed that the movie reused old b-roll footage from Spider-Man 3 (2007).

The movie was inspired by Alien (1979).

It was rumored that this film was a prequel to Venom (2018), but it was subsequently debunked.

This movie was released on March 24, 2017 by Columbia Pictures after being moved up from its previously announced release date of May 26, 2017, to avoid competition with Pirates of the Caribbean: Dead Men Tell No Tales (2017).

This was the second time Hiroyuki Sanada played an astronaut. He previously played one in Sunshine (2007), and both movies also co-starred an actor who had played a Marvel comic book character. Chris Evans played Johnny Storm in Fantastic Four (2005) and its sequel, as well as Captain America in the Marvel Cinematic Universe, and he co-starred in Sunshine (2007) with Hiroyuki Sanada. Ryan Reynolds played the titular character in Deadpool (2016) and co-starred in this movie and, he also played DC Comics character Hal Jordan in Green Lantern (2011).

This is the second collaboration between Rhett Reese, Paul Wernick and Ryan Reynolds. The first was Deadpool (2016).

This was the second time Ryan Reynolds starred in a Daniel Espinosa film. They previously worked together on Safe House (2012).

This was Skydance's first project not to be released by Paramount. Instead, Columbia Pictures produced the film.

Both Hiroyuki Sanada and Ryan Reynolds had starred opposite Hugh Jackman in the "X-Men" character Wolverine movies. Sanada played Shingen in The Wolverine (2013) and Reynolds played Wade Wilson/Deadpool in X-Men Origins: Wolverine (2009).

The movie was released in most countries on director Daniel Espinosa's birthday (March 23rd).

Both Hiroyuki Sanada and Rebecca Ferguson had co-starred in blockbuster films alongside Tom Cruise, with Sanada in The Last Samurai (2003) and Ferguson in Mission: Impossible - Rogue Nation (2015) and Mission: Impossible - Fallout (2018).

This was the sixth feature film of director Daniel Espinosa after Babylonsjukan (2004), Outside Love (2007), Easy Money (2010), Safe House (2012) and Child 44 (2015).

Despite being top billed, Ryan Reynolds had less than forty minutes of screen time in the film.

In the red band trailer of the movie, two character deaths were subtly given away.

Body Count: six (two off-screen, although we do not know how long Dr. North lasts in deep space.)

A student from Calvin Coolidge elementary gives the alien organism the name, "Calvin." One of Ryan Reynolds's first movie Van Wilder: Party Liaison (2002) is set at fictional "Coolidge College."