Ryan Reynolds intended to play the main character, however, scheduling conflicts with The Hitman's Bodyguard (2017) forced him to take a supporting part instead.
Rebecca Ferguson had originally turned down the part of Dr. Miranda North, British, Quarantine Officer, as she thought she would not live up to the standards of the movie. She expressed her anxiety and fear to the producer who advised her to talk with Daniel Espinosa whose philosophy and ideas for the film impressed her enough for her to change her mind and eventually take part in the movie.
In a TV spot commercial, it was revealed that the movie reused old b-roll footage from Spider-Man 3 (2007).
This movie was released on March 24, 2017 by Columbia Pictures after being moved up from its previously announced release date of May 26, 2017, to avoid competition with Pirates of the Caribbean: Dead Men Tell No Tales (2017).
It was rumoured that this film was a prequel to Venom (2018) but it was subsequently debunked.
This was the second time Hiroyuki Sanada played an astronaut. He previously played one in Sunshine (2007) and both movies also co-starred an actor who has played a Marvel Comic Book character. Chris Evans has played Johnny Storm in The Fantastic Four and its sequel (2005-2007) and currently plays Captain America in the Marvel Cinematic Universe and he co-stars in Sunshine (2007) with Hiroyuki Sanada. Ryan Reynolds plays Deadpool (2016) and co-stars in this movie and he also played DC Comics character Hal Jordan in Green Lantern (2011).
This is the second collaboration between Rhett Reese and Paul Wernick and Ryan Reynolds, the first was Deadpool (2016).
This was the second time Ryan Reynolds has starred in a Daniel Espinosa film. They previously worked on Safe House (2012) together.
This was Skydance's first project not to be released by Paramount. Instead, Columbia Pictures produced the film.
Both Hiroyuki Sanada and Ryan Reynolds have starred opposite Hugh Jackman in the X-Men character Wolverine movies. Sanada played Shingen in The Wolverine (2013) and Reynolds played Wade Wilson/Deadpool in X-Men Origins: Wolverine (2009).
Both Hiroyuki Sanada and Rebecca Ferguson have co-starred in blockbuster films with Tom Cruise - Sanada in The Last Samurai (2003) and Ferguson in Mission: Impossible - Rogue Nation (2015).