Mandy Moore is the youngest actor in the main cast.

(2018) Sterling K. Brown's Golden Globe award for Best Actor in this drama TV series made him the first black man to win this category in the ceremony's 75-year history.

Almost completely broke when she landed the role of Kate on the series, Chrissy Metz only had 81 cents in her bank account when she auditioned for the series.

Mandy Moore won her role after an audition suggested by writer Dan Fogelman, whom she knew from working on Tangled (2010).

The same house is used in an outdoor shot of Kate's home as is for Mitch and Cam's home in Modern Family.

When Rebecca and Randall say to each other "I love you", "I love you more", "I love you most", this is a reference to Tangled, in which Mandy Moore starred.

In Season 1 of This Is Us (2016), Chris Sullivan hides the show's People's Choice Award in scenes at Randall's house. As seen on The IMDb Show (2017).

Randall and Beth met in college. Coincidentally, Sterling K. Brown and Susan Kelechi Watson also met in college; they attended the NYU's Tisch School of Arts together.

Actress Chrissy Metz actually sings in the series.

Sterling K. Brown, Denis O'Hare, Chrissy Metz and Alexandra Breckenridge have all appeared in TV shows produced by Ryan Murphy. Brown was in American Crime Story (2016). O'Hare, Metz and Breckenridge were in American Horror Story (2011).

The wall art hanging in Kate's living room is the same as a wall hanging in Jules' living room in Cougar Town (2009).

Ken Olin (Executive Producer) and Timothy Busfield (Director) worked together on Thirtysomething (1987).

Caitlin Thompson, who plays Madison, is the wife of Dan Fogelman, the creator of the show.

The same art work representing a drawing of a man, appears in Grace & Frankie in the den of Robert Hanson (Martin Sheen) as does in the home of Beth & Randall.

Oliver Hudson auditioned to play Jack.

Sterling K. Brown and Susan Kelechi Watson both also appeared on "Third Watch".

Sylvester Stallone appears in the second season as himself and Kate tells him that her father (played by Milo Ventimiglia) has seen every Rocky movie. This is ironic because Milo Ventimiglia actually played Rocky Balboa's son.

Jack is the only main character to appear in every episode in the first season.

There are a few hints in the pilot that Kevin and Kate are twins and that Randall is their brother. For example, in the scene where Randall gets an email saying that they found his biological father, an email entitled "It's Our Birthday Bro" can be seen in his inbox from Kevin.

In the show, Mandy Moore plays Chrissy Metz's mother. In reality, Chrissy is four years older than Mandy.

Kevin's ex-girlfriend, Sloane, is played by Milana Vayntrub, who also plays the saleswoman from the AT&T Wireless commercials.

A persistent theme in the storylines about Randall's childhood is the fact that despite their best intentions and love for their son, Jack and Rebecca Pearson repeatedly show that they are naive and ill-prepared for the realities of raising a black child. As several TV writers (such as Jezebel's Kara Brown, Hypable's Tariq Kyle, and The Medium Is Not Enough's Rob Buckley) noted, one of the more subtle examples of the Pearsons' obliviousness on this matter is that until they changed his name from Kyle to Randall, they had given their three children names that all started with Ks, meaning that together their children's initials were KKK.

The fitness class with green drumsticks (ripstix) Kate takes part in is a real fitness class called Pound-rockout, developed by Kirsten Potenza in Los Angeles. There are classes all over the globe.