(2018) Sterling K. Brown's Golden Globe award for Best Actor in this drama TV series made him the first black man to win this category in the ceremony's 75-year history.
Mandy Moore is the youngest actor in the main cast despite playing the mother of Randall, Kate and Kevin.
Almost completely broke when she landed the role of Kate on the series, Chrissy Metz only had 81 cents in her bank account when she auditioned for the series.
The same house is used in an outdoor shot of Kate's home as is for Mitch and Cam's home in Modern Family.
Mandy Moore won her role after an audition suggested by writer Dan Fogelman, whom she knew from working on Tangled (2010).
When Rebecca and Randall say to each other "I love you", "I love you more", "I love you most", this is a reference to Tangled, in which Mandy Moore starred.
Randall and Beth met in college. Coincidentally, Sterling K. Brown and Susan Kelechi Watson also met in college; they attended the NYU's Tisch School of Arts together.
In Season 1 of This Is Us (2016), Chris Sullivan hides the show's People's Choice Award in scenes at Randall's house. As seen on The IMDb Show (2017).
Sterling K. Brown, Denis O'Hare, Chrissy Metz and Alexandra Breckenridge have all appeared in TV shows produced by Ryan Murphy. Brown was in American Crime Story (2016). O'Hare, Metz and Breckenridge were in American Horror Story (2011).
Ken Olin (Executive Producer) and Timothy Busfield (Director) worked together on Thirtysomething (1987).
The wall art hanging in Kate's living room is the same as a wall hanging in Jules' living room in Cougar Town (2009).
Caitlin Thompson, who plays Madison, is the wife of Dan Fogelman, the creator of the show.
The same art work representing a drawing of a man, appears in Grace & Frankie in the den of Robert Hanson (Martin Sheen) as does in the home of Beth & Randall.
Sterling K. Brown and Susan Kelechi Watson both also appeared on "Third Watch" and they have known each other since grad school.
Milo Ventimiglia was nominated for the 2018 Emmy Award in the Lead Actor in a Drama Series category for his role as Jack Pearson in This Is Us (2016), but lost to Matthew Rhys from The Americans (2013).