Adam Scott took over the role of Ben from Bradley Cooper, who could not appear due to scheduling conflicts. The change in Ben's appearance is explained by saying that he had a nose job to fix his deviated septum.
Because of scheduling conflicts, David Hyde Pierce (Professor Henry Neumann) was only able to appear in one scene of one episode of this installment, and in that scene, Neumann is only shown on a screen. Neumann is ostensibly calling from his office at N.A.S.A.'s Cape Canaveral, Florida, but in the background of the office, there is a bookcase holding multiple Emmys. In an August 2017 interview with Vulture.com, David Wain explained, "David Hyde Pierce was directing a play in New York during the whole shoot, so there was just literally no chance he could come. He had no time, so we thought, as we'd done in other ways in the past, let's lean into that even more. So, we decided to literally shoot it on Skype in his apartment and make it clear that we're doing that." The Emmys on the bookcase are Pierce's own from his years on Frasier (1993).
Even though Samm Levine voiced Arty in Wet Hot American Summer (2001) and Wet Hot American Summer: First Day of Camp (2015), this is the first time he has appeared on-screen as the character.
Paul Rudd (Andy) and Skyler Gisonndo (Jeremy) both played the character Tommy Doyle in the Halloween film franchise. Rudd portrayed him in Halloween: The Curse of Michael Myers (1995). Gisonndo portrayed him in Halloween (2007).
Marks the second time Adam Scott played a character named Ben alongside Amy Poehler. The first being Parks and Recreation (2009).