Donald Glover originally planned to play the lead role of Cassius Green, but was unable to do so due to scheduling conflicts with Solo: A Star Wars Story. He recommended his Atlanta co-star LaKeith Stanfield for the role instead.

At one point, Detroit wears a pair of earrings with the phrases BURY THE RAG and DEEP IN YOUR FACE. These are lyrics from "The Lonesome Death of Hattie Carroll" by Bob Dylan, which is a protest song about a poor African-American woman murdered by a wealthy white man. ("Bury the rag deep in your face/ Now's the time for your tears".)

Over 60 scenes were shot in 28 days.

The voice of the elevator is played by Rosario Dawson. As seen on The IMDb Show (2017).

Director Michel Gondry is paid tribute in the director's name for the claymation sequence, Michel Dongy. Gondry's influence is clear in the scenes where the garage transforms into the luxury room.

The movie was filmed in Oakland, California during the summer of 2017 concurrently with Blindspotting (2018).

Most of the crazy riot scenes were shot in downtown Oakland, California.

Naturally green-eyed Armie Hammer wears a light blue contact lens in one of his eyes.

Mistah F.A.B.: Bay Area rap legend Mistah F.A.B. makes a cameo as the passenger that drives by laughing at Cassius Green.

W. Kamau Bell appears in a cameo, commenting on the horse statue.

After sniffing the cocaine, Cassius is splashed by water from a nearby car, causing him to trip. This may mean that his transformation has already begun, as baby horses have weak legs.