The Russian word that appears at least twice (supposedly the manufacturer of a piece of electric equipment) is 'Covfefe' in Cyrillic letters.

Jodie Foster's first acting role since the sci-fi action film Elysium (2013).

The hotel is named for the Greek goddess Artemis, who was born in secret to protect her from the wrath of Hera, queen of the gods.

Drew Pearce's directorial debut.

Despite the fact that many of the characters' real names are revealed in the film, the end credits only list their code names. The Nurse, Waikiki, Niagara and so on.

Singer-songwriter Father John Misty is said to make an appearance in this film.

Both Zachary Quinto and Sofia Boutella starred together in Star Trek: Beyond (2016).

There are four patient rooms in the Hotel Artemis: Niagara, Honolulu, Accapulco and Nice. Patients assigned to these rooms are only ever referred to by that room's name. Sterling K. Brown's character is called "Waikiki," because he shares the Honolulu room with his brother.

As seen on the official trailer, Hotel Artemis 10 rules are : 1. While on the premises, no fighting with or killing other patients. 2. No disrespectful words or actions allowed against Hotel Artemis staff. 3. No guns of any type of weapon permitted through the gates. 4. Memberships must be paid for in full and in advance. 5. Prior but lapsed members will not be admitted 6. No photography or video allowed. 7. No outside food or drink. 8. Absolutely no visitors. 9. If member is found to have compromised or led to compromise of location, membership will be revoked. 10. Hotel Artemis rules are final and non negotiable.

Kenneth Choi and Sterling K Brown both appeared in "The People vs OJ Simpson" (as Judge Lance Ito and Christopher Darden, respectively).

-To promote the film, Global Road Entertainment released a set of character posters, each featuring an homage to a famous literary or film reference from Los Angeles, such as Sterling K. Brown merged into the book cover for Raymond Chandler's novel The Long Goodbye and Charlie Day merged into the film poster for American Gigolo.

Both Zachary Quinto and Jenny Slate starred together in Aardvark (2017).

Sterling Brown, Dave Bautista & Jeffrey Goldblum all play in Marvel Cinematic Universe (MCU) movies; Brown in "The Black Panther" Bautista in the "Guardians of the Galaxy" & "Avengers Infinity War" & Goldblum in "Thor Ragnarok".

The cigarette case that Nice (Sofia Boutella) uses to blow up the power box reads "FUMER TUE", which is French for "SMOKING KILLS"

Towards the end when Jodie Foster is leading Sterling K. Brown out of the building, a sign is shown with Cyrillic letters that spell the word "covfefe."

At the end, "The Nurse" refers "Waikiki" to a "dark room" in Las Vegas. Dark room is a longstanding underworld term for an emergency room or similar medical facility where criminals can go without the police finding out. The Hotel Artemis is a dark room, albeit a very elaborate one.