The house of Russell Tillman is the same house that Karen lives in from Shameless another Chicago based TV show.

Nate Santana (Kirby Michaels) plays Dr. James Lanik on Chicago Med (season 3: 2018-season 4: 2019)

Zach Greiner played the priest in this episode played a preacher as well as Andy the con man on the TV show Deadwood(2004).