The series reunites Alicia Silverstone with her Beauty Shop costar Mena Suvari, but in that film the two are involved in a huge fight while in this series they are best friends

The character of Bonnie was inspired by Kyle Richards' own mother, Kathleen Mary Richards. The show is a fictionalized depiction of Kyle's upbringing, inspired by her mother but not an exact autobiographical reenactment of her life. For example, Kyle has two sisters whereas on the show, Bonnie only has two daughters, not three. Bonnie's friend on the show was named after Kathleen Mary Richards, although she is not based on her. The character Kathleen represents female friends that Kyle Richards' mother had who frequented her life.

This show continues Mena Suvari's habit of appearing in projects with the word "American" in the title: American Pie, American Pie 2, American Beauty, American Horror Story and American Reunion.

American Woman is co-executive produced and based on the life of Real Housewives of Beverly Hills star Kyle Richards.

Kyle Richards stated in 9.6 of Real Housewives of Beverly Hills that American Woman was not picked up for a second season.