Ryan Reynolds & Taika Waititi previously co-starred together in Green Lantern (2011).
This is the second time Ryan Reynolds has played a character named Guy. The first time was in the animated film "The Croods".
The movie is set in a fictional, intra-video-game locale called Free City. Its teaser trailer opens with an establishing shot of what is visibly Pittsburgh, however, and its remainder appears to have been filmed in the Boston area. Local landmarks such as Faneuil Hall and the 75 State Street complex are clearly visible.