The song was also featured in the video game Grand Theft Auto: San Andreas on the fictional radio station "Radio X" (singer Axl Rose voices a radio DJ in the game on a separate station).

The song was featured in the music video game Guitar Hero III: Legends of Rock, along with an in-game representation of Slash, who becomes unlocked as a playable character after defeating him in a guitar battle.

During an interview with Rolling Stone magazine about the music video, Guns N' Roses' manager at the time, Alan Niven, said that he "came up with the idea of stealing from three movies: Midnight Cowboy, The Man Who Fell to Earth and A Clockwork Orange."