Freddie Highmore revealed that he was initially turned down for the role of Shaun Murphy, being deemed too young. The producers told him they wanted someone who was at least 25, he replied with "but I AM 25."
All three of the actors playing the surgical residents were born in London, UK. Freddie Highmore and Antonia Thomas both use American accents, while Chuku Modu speaks naturally.
Nicholas Gonzalez (Dr. Melendez) comes from a medical family, his father and brother both being surgeons and his mother a bookkeeper at South Texas Radiology (San Antonio). His brother acted as an uncredited medical consultant to him on set.
Based on Korean (KBS2) medical drama Good Doctor (2013), original screenplay by Jae-bum Park, who received Korean Drama Awards.
Based on a South Korean show Good Doctor (2013) where the main character is Park Shi Ohn. His given name can be broken down to Shi -- to see and Ohn -- the whole or entirety. The main character's name in the US show is both an actual western name and a transliteration of the original.
Dr. Alex Park (Will Yun Lee) & his wife Mia Wuellner (Jennifer Birmingham Lee) are a couple off-screen.
The Centers for Disease Control (CDC) estimates that 1 in 68 children (or 14.7 per 1,000 eight-year-olds) in multiple communities in the United States has been identified with autism spectrum disorder (ASD) 
One of the St. Bonaventure Hospital exterior shots is the Surrey Civic Center near Vancouver, Canada.
This is the first medical drama series for Richard Schiff (Dr. Glassman). Ironically, he has stated that in reality he actually hates hospitals.
On the donor wall of the set for San Jose St. Bonaventure Hospital is a placard that reads "The Bates Family," a nod to actor Freddie Highmore's role as Norman Bates in Bates Motel (TV Series 2013-2017)
These actors were also in was in House (2004) , another show created by David Shore. Lisa Edelstein Robert Sean Leonard Beau Garrett (Jessica Preston) for one episode
Richard Schiff and Beau Garrett were previously on another series, Criminal Minds: Suspect Behavior (2011). Garrett was one of the stars of the series and Schiff was a regular guest star.
Vered Blonstein is the only actress to portray a female autistic character on the series.
Richard Schiffs characters name (Glassman) is loosely based off his religion as Toby in The West Wing, who's name was Rabbi Glassman.
Will Yun Lee (Dr. Alex Park) and Daniel Dae Kim (Dr. Jackson Han and one of the producers of the show) were both on Hawai'i Five-0, Kim in a starring role as Chin Ho Kelly for the first seven seasons and Lee as recurring character Sang Min.