There are two references to Alcoholics Anonymous in the movie "Serenity". The first reference: "Serenity" the name of Matthew McConaughey character's boat in the movie. "Serenity" is a word frequently used in AA. Even in the title of a meetings opening/closing prayer, "The Serenity Prayer" The second reference: at about an hour & ten minutes in, McConaughey character, Baker Dill/Dillon, says he "probably needs to see Dr Bob." Dr Bob is what members of AA call Robert Holbrook Smith, who Co-founded Alcoholics Anonymous.
This is the second collaboration between Matthew McConaughey and Anne Hathaway. They previously both appeared in Interstellar (2014).
The film strongly references some famous literary works, including Moby-Dick (the protagonist's Captain Ahab-like obsession), The Old Man and the Sea (the character's obsession to catch the one fish that got away), The Rime of the Ancient Mariner (the same symbolic bird always following the boat), and Shakespeare's The Tempest (the "we are such stuff as dreams are made on" quote).
Fontaine Fishing Company, that Reid Miller works for in the movie, is likely a reference to Fontaine Industries from the video game Bioshock.
This is also the second collaboration between Matthew McConaughey and Djimon Hounsou. They previously collaborated in Amistad (1997).