Nick Kroll voices up to twelve characters, including Nick Birch, Maurice the Hormone Monster, and Coach Steve.

When Nick and Jessi are having dinner, their chairs are a reference to Fast Times at Ridgemont High (1982).

Nick Kroll, Mark Duplass, Paul Scheer, Jason Mantzoukas, Neil Casey, June Diane Raphael, Rob Huebel, and Zach Woods all appeared in the show The League (2009-2015).

Nick Kroll, Fred Armisen, Maya Rudolph, Richard Kind and Paula Pell all appeared or had cameo rolls in another Netflix original series, Unbreakable Kimmy Schmidt.

In Episode 7, "Requiem for a Wet Dream", the character Matthew makes a reference to the TV series "Girls". Andrew Rannells, who voices Matthew, plays a recurring character on "Girls".

Both Nick Kroll and John Mulaney attended Georgetown University.

Jason Mantzoukas, Paul Scheer, and June Diane Raphael are the hosts of the podcast How Did This Get Made, and Nick Kroll was the guest on their first episode.

A lot of of Howard Stern catch phrases are used.

Both Nick Kroll and Jenny Slate were on films from Illumination Studios.

In season 1, episode 6, "Pillow Talk", when Nick and Andrew are talking to Duke Ellington (voiced by comedian Jordan Peele) in NYC after Duke's encounter with the elderly lady, there is a billboard behind them with Daniel Kaluuya's face on it. It's a movie advert that reads, "Stay Out". This is a spoof of the movie "Get Out", Jordan's directorial debut film that has been widely hailed by critics as a must-see cross between psychological horror and comedy.

During the sixth episode when Andrew and Nick visit the city, there's a billboard for the show "Oh, Hello on Broadway" which Nick Kroll and John Mulaney wrote and stared in together.

The Ponytail Something's last victim in episode 10 "Pornscape" is Karl Lagerfeld, head creative designer of the fashion house Chanel.

The main plot in Episode 10 "The Pornscape" is based off Francis Ford Coppola's "Apocalypse Now" (1979).