The title card for the first season starts off clean, and gets blood on it with each episode.
The title card for the third season glitches between different colors for each episode, representing the alternate Invincibles from alternate universes.
The title card for the second season breaks away with each episode, to reveal a new title in blue-black colors.
Generally, the title card appears whenever someone says a dialogue that ends with "Invincible" (either as a name or a description).