According to showrunner Wellesley Wild and co-executive producers Gabe Swarr and Tom Minton, producer Steven Spielberg was at every pitch meeting and insisted maintaining most of the elements of the original show including the original voice cast.

A clip, introduced as the cold open from the first episode of the revived show, was released during the Animaniacs panel at the 2020 New York Comic Con, parodying producer Steven Spielberg's own Jurassic Park with a caricature of Spielberg in the role of John Hammond having "reanimated" the Warners.

Neither original series creator Tom Ruegger nor any of the original series writers return. Warner Bros. did not consult them for this revival.

Thaddeus Plotz has retired and has been replaced by a new, female CEO named Nora Rita Norita.

This marks the second time comedian and actor Ralph Garman has provided voice work for a Steven Spielberg production after 2008's Eagle Eye.

This is the second Steven Spielberg production that Jon Bailey has provided voice work on after 2018's Bumblebee, where they took over the role of Soundwave and Shockwave respectively, both previously voiced by Frank Welker.

In this update, one of the actors Dot likes is Chris Pine. Both Chris Pine's father Robert Pine and Dot's voice actress Tress MacNeille guest starred on the series Avatar: The Last Airbender.