The song peaked at number 24 on the US Billboard Hot 100.

The song peaked within the top 40 in Australia, Ireland, New Zealand and the United Kingdom.

The music video was directed by Diane Martel.

Minaj promoted the song by performing it live at the BET Awards 2014.

On May 19, 2014, Minaj revealed the single's cover art on Instagram.

"Pills n Potions" is a piano ballad "framed in the druggy imagery of mix-tape rap".

Chris Payne of Billboard said the song coupled a chorus "reminiscent of a Rihanna ballad" with rapped verses.

Kory Grow of Rolling Stone opined that the song shows Minaj "sublimely (and maturely) rising above her detractors, even singing that she still loves them."

Zach Frydenlund of Complex called "Pills n Potions" a "monster of a song".

Chris Payne of Billboard felt Minaj was sincere in her delivery of the song's personal lyrics, and went on to call it a "crowd pleaser" with something for every listener to enjoy.

Gil Kaufman of MTV News wrote that the song was "actually a huge move back into the pop game, setting Minaj up for what could be her biggest cross-over hit".

Marc Hogan of Spin found the song's message confusing, but praised Minaj's rapping and said: "when we hear that Rihanna-like 'I still lo-uh-uh-ve' hook blasting out of car windows this summer? We'll probably still lo-uh-uh-ve it."

Kory Grow of Rolling Stone noted that "Pills n Potions" was the "diametric opposite" of Minaj's previous single, "Lookin Ass".

XXL featured the song on their mid-year list of 25 Best Songs of 2014, commenting that "despite the slow tempo of the song, Nicki was still able to supply her classic witty lines with a hard undertone".

The video of "Pills N Potions" was released on June 9, 2014 via Minaj's Vevo on YouTube.

In the United States, "Pills n Potions" debuted at number 47 on the Billboard Hot 100 for the week ending June 7, 2014; It went on to peak at number 24 on the chart.

It sold 84,000 copies and amassed 709,000 domestic streams within its first four days of release.

As of December 2015, the song has sold 922,000 copies in the United States.

Australia (ARIA) Platinum certification with 70,000 sales.

Belgium (Ultratip Wallonia) peak position 8, 2014.