The Sam and Dean referenced in the first episode are the Winchesters from Supernatural

One of the first lines of the first episode has Isaac Hastings (Mario Van Peebles) saying, "We improvise, we adapt, we overcome." This is the exact mantra that's said by Gunnery Sergeant Tom Highway (Clint Eastwood) and then repeated by Stitch Jones (Mario Van Peebles) in Heartbreak Ridge.