Unlike in the movie, in which they were voiced by adults, George and Harold are voiced by actual kids in this series.
Jerome Horwitz elementary is named after Curly Howard of the Three Stooges. Jerome was Curly's real name.
This series takes place in Piqua Ohio. There is an actual town in Ohio named Piqua. However in the show the characters pronounce the name of the town incorrectly. In the show they pronounce the "i" in Piqua with a long e sound. The actual town is pronounced using a short i sound.