A fun show...just don't take it too seriously Until I saw Spider-Man 2 in 2004, I knew nothing about Marvel superheroes. Period. So, I saw Spider-Man 2, then I read the first five or ten years of Spider-Man comics (in B&W), then I saw Spider-Man: The Animated Series. So I knew the backstories of all Stan's characters, but not much about Venom, Hobgoblin or anyone else from the later timeframe.
From that point of view, here's my take on the show:
1. A lot of reviews on here complain about the censorship. This was not the writers' fault, and I don't find it annoying. Sure, whenever anybody wanted to say "kill" they said "destroy" instead, but they didn't say either one often enough to bug me. And the laser guns, though totally unbelievable in modern-day New York, didn't bother me because this is a New York where people walk on walls, J. Jonah Jameson has a TV show, and there's a giant invisible Heli-carrier suspended above the city.
2. The animation was very cheaply done. I noticed particularly in the two-part X-Men crossover, Beast starts out about a foot taller than Wolverine and ends up about a foot shorter. And they re-used their explosion footage till you'd think it would wear out. And I can't stand to look at Captain America's face in the "Secret Wars"--he looks sort of like a plush toy. But most of the villains look terrific; just compare this Venom and the Spider-Man 3 movie Venom, for example.
3. The scripting varied widely. For the most part, it was okay to great, but there were spots where it was just wince-producing. For example, I loved how Venom sacrificed himself to save the world (and his girlfriend), but the girlfriend sounding off about it afterwards--yeesh! That said, Venom himself was scripted much better (I thought) than in Spider-Man 3, with the same totally irrational sense of humor he had in the comics.
4. The voicecasting--wow. I'll just review some of the voices individually. Hobgoblin... This was the first time I'd ever heard Mark Hamill, and he was terrific! My whole family agrees that the Hobgoblin is much cooler than the Joker, mainly due to his voice (and scripting). Aunt Anna Watson... Majel Barrett-Roddenberry was totally perfect. As Star Trek: TOS fans, we think of her as Nurse Chapel rather than Lwaxana Troi, and when we found out who'd voiced Anna Watson we were all like, "My gosh, she's perfect!" Dr. Octopus... He sounds so German, and so Octopussy, it's hard to believe Efrem Zimbalist Jr. has been Batman's butler for years. Venom... This was the first Venom I ever saw or heard, my standard of comparison. The Eddie Brock voice got a little whiny at times, but Venom with that double echo was amazing--even if he never did get to say "spleen".
5. The story lines, while they were never taken directly from the comics, were usually interesting re-interpretations of comic-book story lines that respected the characters and their motivations. Granted, making Electro the Red Skull's son was completely off-the-wall, even if they were in a hurry to get into the whole Secret Wars/Spider Wars thing before they got canceled. But the "Make a Wish" two-parter--based on two comic-book stories, "The Boy Who Collects Spider-Man" and the storyline where an amnesiac Spider-Man teamed with Doc Ock--was a really terrific use of both ideas and neatly overcame the difficulty of putting supervillain fights in a kid-with-cancer story. (Not to mention, Mousie the cab driver was hilarious!)
On the whole, I've enjoyed this show, even if I find it advisable to shut my eyes in some places due to the sheer badness of the animation. I'd recommend it as an introduction to Spider-Man, with the caveat that you'd better check your facts against a Guide to the Marvel Universe before using them in any fan-fic or anything; I'd also recommend it for little boys who are not yet bored of explosions, and for people (like my mom) who are more interested in Peter and MJ's relationship than in fight scenes.
So, if you're only interested in good guys beating up bad guys, go watch a Bruce Timm show. If you're looking for high-end animation, try "The Incredibles." But if you want a fun, family-friendly show about the problems of a teenage science nerd who happens to walk on walls and get beat up by hi-tech lunatics... this is the show you've been looking for.