Meech smuggles drugs from Las Vegas as a test to secure a new plug for BMF, a vicious gangster from the Brewster Projects, K-9; Terry begins his new car-ride business with Charles after leaving the drug game.
With Meech barely out of the hospital and still bleeding out, Terry assumes command of BMF, yet BMF is 'Runnin on E' strapped for cash, out of product, and down to their last men.
On the run, broke and in search of a new plug, Meech and Terry discover the Black Mecca of Atlanta where they connect with old friends and make new allies.
Meech and Terry return to Detroit from Atlanta with a product and a new technique to flood the streets with BMF product. Meech links up with Sterling and the PA Boys to continue his quest to kill Lamar.
The Flenory brothers travel to Atlanta during "Freaknik" to set up a new distribution hub for BMF and reconnect with their business associates Ty Washington and Goldie; not everyone survives the road trip.
Meech and Terry finally handle Detective Bryant, Lamar and B-Mickie before charting the next big step for BMF's expansion, which will change the course of their relationship forever.