The Pope's Exorcist takes creative liberties with the real Father Amorth's life and exorcisms, making the story more fantastical than reality. The movie depicts Father Amorth as an established exorcist who has been saving souls for years, whereas in reality he didn't become an exorcist until he was 61. While the movie's plot and characters are fictional, they still capture the essence of the battle between good and evil that Father Amorth believed in.

The horror movie The Pope's Exorcist is based on the true story of the Chief Exorcist of the Diocese of Rome, though it makes some big changes to Father Amorth’s real claims. Starring Russell Crowe as Father Amorth, who is purported to have participated in over 100,000 exorcisms over 30 years, The Pope's Exorcist jumps right into the action, with the priest using all the skills at his disposal to help rid a 10-year-old boy named Henry of an ancient demon.