Maze Runner 4 could answer burning questions and fill plot holes from the previous movies, providing clarity on Teresa's presence in the Maze and the origin of the Flare Virus. The movie could offer clarification on how the cure is harvested from immune individuals and why the Maze was necessary for finding the cure. Maze Runner 4 could delve into Wckd's true motivations and provide background information on Thomas' involvement with Wckd and Gally's actions in the first movie.

While the dystopian trilogy concluded half a decade ago, Maze Runner 4 could provide answers to many burning questions. The 2010s saw a spike in young adult book adaptations like The Maze Runner, and the overall success of the franchise has left the door open for more stories. The Ballad of Songbirds and Snakes prequel to the Hunger Games movies has raised hopes that other popular teen dystopian movies would get prequels of their own.