House often faces rare and challenging medical cases, but some episodes stretch the truth for dramatic effect. Errors and inaccuracies occasionally occur, such as inaccurately diagnosing a heart infection or relating unrelated symptoms to a diagnosis. While most cases reflect real medical phenomena, the show sometimes takes liberties with medical plausibility and uses fictional elements.

House may be a brilliant TV doctor, but that doesn't mean that all the cases that are featured during the series are completely accurate. House stars Hugh Laurie as the titular character with a gift for diagnosing and treating patients with unusual ailments. Often, the cases that come across House's desk can be extraordinarily rare, highly unusual, and a challenge for other doctors to properly assess, but thanks to his encyclopedic knowledge of illness and his critical thinking, House usually manages to save the day.

However, there have been cases on the show that defied...