Since its inception in 1997, One Piece has become one of the most popular anime franchises in the world. The adventures of its protagonist, Monkey D. Luffy, span several decades and tens of narrative arcs, but after over 25 years of syndication, the series is finally entering its final saga. Before One Piece draws to a close, there are still plenty of major developments that need to occur in its narrative. This includes the Awakening of various Devil Fruits, several of which belong to the series' most important characters.

Almost any Devil Fruit increases the strength of its user. However, in a few rare instances, an individual can Awaken their Fruit, giving them access to abilities that are significantly more powerful. Important figures like Donquixote Doflamingo, Trafalgar D. Water Law, and even Monkey D. Luffy have achieved this feat, and using their newfound powers, they each staked a claim as the Grand Line's most influential pirates.