Fox will show a new side — or rather, all sides — of a group of male celebrities in an upcoming special.

The network has signed up Anthony Anderson, Taye Diggs, NFL All-Pro Chris Jones, Tyler Posey, Dancing With the Stars judge Bruno Tonioli and James Van Der Beek to take part in The Real Full Monty. The two-hour special, set to air in the fall, will raise awareness for prostate, testicular and colorectal cancer testing and research — and end with the troupe performing a striptease act.

The Real Full Monty is based on a series of British TV specials, which in turn are inspired by the 1997 movie The Full Monty, about a group of regular guys who form a male striptease act.

“Don’t die of embarrassment. Get checked! That’s the message behind The Real Full Monty special,” said Anderson, who’s also an executive producer. “I am honored...