Adrien Brody's character having sex with the creature was controversial but central; Natali refused to cut the scene. Despite divisive audience reception, Splice garnered a cult following among genre enthusiasts and horror fans. Splice's blend of sci-fi and body horror, inspired by Alien and 2001: A Space Odyssey, remains impactful 15 years later.

Splice director Vincenzo Natali reflects on its controversial scene and legacy 15 years later. Co-written and directed by Natali who was previously known for Cube, Cypher, and Nothing the sci-fi horror film from 2009 follows two genetic engineers who splice together DNA to create a human-animal hybrid creature called Dren, who they raise to disastrous results. Academy Award winners Adrien Brody and Sarah Polley lead the cast alongside Delphine Chanac as Dren, Brandon McGibbon, Simona Maicanescu, and David Hewlett.

Now, 15 years after the film's release, Natali reflected on Splice's controversial sex scene and its overall legacy in an interview with IndieWire.