Splice is a modern, terrifying take on Frankenstein, exploring the dangers of unchecked ambition in science. Both films feature tragic creatures created by science, turning violent due to neglect and mistreatment. The lead characters in Splice and Frankenstein are blinded by ambition, leading to catastrophic consequences for all involved.

Splice is a highly memorable and truly terrifying movie, and it pairs perfectly with a classic of the horror genre. Released in 2010 to solid reviews (but an ultimately lackluster box office), Splice fused sci-fi and horror to explore questions about life and humanity in an age where science could transform people into something new. It's far from the only movie to use those genres to explore inquisitive reflections on the nature of life and death, speaking to the universal power of those themes as Splice even takes inspiration from real life. In fact, those shared qualities actually give an inherent connection...