John Mahoney's passing deeply impacted co-stars, particularly Kelsey Grammer, who considered him like a father. The Frasier revival honored Mahoney's character by addressing his absence head-on in a touching tribute episode. The bond between Mahoney and Grammer went beyond their on-screen relationship, reflecting a real familial love.

John Mahoney was famous for his role as Martin Crane on Frasier and his passing was a real loss for his castmates and crew, particularly Kelsey Grammer. Frasier, a spin-off series from the hit sitcom Cheers, was itself a massive cultural touchstone. Over 11 seasons from 1993 to 2004, viewers got to know the uptight Dr. Frasier Crane (Grammer) and his friends and family in Seattle, Washington. His father, Martin (Mahoney), is a retired police detective and an outspoken thorn in his son's side, though the two deeply love one another.

In 2023, the first season of the Frasier revival premiered, introducing new characters and returning some beloved old ones.