Minions: The Rise of Gru performed exceptionally well at the box office, indicating that, under the care of the Minions, the Despicable Me film franchise is alive and well. This franchise got its start in 2010 with Despicable Me and continually succeeded with its brand of energetic, family-friendly humor through 2022's The Rise of Gru, the fifth film in the beloved series. One of the most entertaining aspects of the film series is the colorful cast of villains who try to thwart the franchise's antihero, Felonious Gru, or his Minions.

The villains each have a unique gimmick that sets them apart and an ample supply of zany weapons at their disposal. They also have some of the best villain names in the history of villains. Although all the Despicable Me/Minions villains are funny and diabolical in their own right, a few of them stand out from the pack.

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