Lucy Lawless reprises her role as Lucretia in a guest-starring capacity to set up the show's alternate timeline. The cast includes the returning Nick Tarabay as Ashur, in addition to Graham McTavish, Ivana Baquero, and others. Spartacus: House of Ashur will explore an alternate timeline where Ashur survives and gains ownership of the gladiator school.

Spartacus: House of Ashur unveils one more returning star, as another cast member is confirmed for the Starz revival. Described as an erotic and thrilling experience by Starz, House of Ashur will look to build on the success of the original Spartacus series. In particular, it will focus on what might have happened if Ashur hadnt died on Mount Vesuvius at the end of Spartacus: Vengeance, highlighting the different paths that might have been taken. Nick Tarabay is confirmed to return as Ashur for the ten-episode series, along with Steven S. DeKnight as showrunner and executive producer.