Jesse Turner's return as the Antichrist could kickstart a possible Supernatural season 16, satisfying fans by addressing unresolved storylines. Supernatural's stakes problem could be solved if the Winchesters take on Jesse, a powerful foe free from Chuck's story. Jesse's storyline as a powerful being who could destroy Heaven remains one of the biggest unresolved plots in Supernatural.

One particular unresolved Supernatural story from 2009 could be the ideal starting point for a possible season 16. Supernatural has had a fantastic run since it first aired in 2005, breaking the record for the longest-running American live-action fantasy series with the release of its 11th season. It is also responsible for the fame of the Supernatural cast, allowing stars Jensen Ackles and Jared Padalecki to become legacies in the genre. However, the American series ended its run in 2020 after 15 seasons, much to the disappointment of its dedicated fandom, who wish the series had a 16th season.