The former NBC sitcom A.P. Bio has a robust cast full of hilarious main and supporting characters. Mike O'Brien of Saturday Night Live acclaim created the original sitcom, which first premiered on February 1, 2018. The show is centered around professor turned high-school teacher Jack Griffin, who is played by Glenn Howerton of It's Always Sunny in Philadelphia. A.P. Bio follows Jack as he transitions from being a philosophy professor at Harvard University to an A.P. Biology teacher at his hometown high school after falling from grace due to a YouTube video.

A.P. Bio ran for two seasons on NBC before moving to Peacock for its final two seasons. The series was canceled twice even though it maintained an impressive Rotten Tomatoes score of 88%, with its second and third seasons earning perfect 100% critic scores. Despite the positive reviews of A.P. Bio, there was not enough consistent viewership for the series to continue past four seasons.