Dune: Prophecy episode 5 introduces the concept of the Omnius Plague to television fans, and there's more information to be obtained about it from the books. This era of the Dune timeline is prominently covered in the expanded novels by Brian Herbert and Kevin J. Anderson. Their books are prequels to Frank Herbert's original novels, with Dune Sisterhood being the basis for the HBO TV series. The Omnius Plague is an idea original to those expanded novels, though its purpose is rooted in ideas that originate from Frank Herbert's classics.

Olivia Williams plays Tula Harkonnen in Dune: Prophecy's cast and episode 5's plot sees her working with an unlikely ally. Mother Superior Raquella Berto-Anirul was the leader of the Sisterhood who passed away in episode 1's flashbacks, allowing Valya to take over. In episode 5, Raquella's descendent, Sister Lila, channels her personality for a while, using her knowledge to aid...