John C. Reilly will soon appear on the big screen as Buffalo Bill in “Heads or Tails?” a surreal Western by Italian directorial duo Alessio Rigo de Righi and Matteo Zoppis (“The Tale of King Crab”). The film is inspired by a true event that took place during Buffalo Bill’s stay in Italy.

Along with the Oscar-nominated U.S. actor – who co-starred with Joaquin Phoenix in Jacques Audiard’s Western “The Sisters Brothers” – the top notch “Heads or Tails?” cast also comprises rising French star Nadia Tereszkiewicz and Italy’s Alessandro Borghi, in lead roles, and Argentina’s Peter Lanzani.

Italian cowboys known as “butteri” –– and hailing from the central Italian plains of northern Lazio up through the coastal Italian region of Maremma into southern Tuscany — have a long-standing connection to Buffalo Bill and the history of America’s Wild West.

Buffalo Bill, born William F. Cody, was a...