Abs-cbn’s Star Cinema is betting big on romantic comedy again, setting a March 28 theatrical release for “My Love Will Make You Disappear” across the U.S. and Canada. The film marks the first big-screen team-up of Filipino stars Kim Chiu and Paulo Avelino, whose combined social media following tops 40 million.

Directed by Chad Vidanes and written by Patrick Valencia and Isabella Policarpio, the rom-com follows Sari (Chiu), a woman convinced she’s cursed because every man she loves vanishes. Enter Jolo (Avelino), a brooding landlord grappling with a failing apartment complex. Their paths cross as they fight to save a community from displacement, but Sari’s supposed curse threatens their budding romance.

While Chiu and Avelino have already sparked chemistry in TV hits “Linlang” and “What Happened to Secretary Kim,” this marks their first feature collaboration. Chiu brings her box office draw from hits like “Bride for Rent” and “The Ghost Bride,...