Many actors have walked through the revolving door of the NCIS Major Case Response Team's Navy Yard headquarters. Some of them have been relatively fresh faces, but "NCIS" has also filled many roles with actors who had plenty of pedigree even before they joined the show. Actors like Mark Harmon, David McCallum (Dr. Donald "Ducky" Mallard), Lauren Holly (Director Jenny Shepard), Gary Cole (Alden Parker), and Wilmer Valderrama (Nick Torres) had all tasted success in previous projects before "NCIS," but even they pale in comparison to one name who was once considered for a big role in the show: Jennifer Aniston.

In a joint oral history interview with The Hollywood Reporter, several makers of the show discussed casting, and they revealed that Aniston's name was once on the table to play the tragic Caitlin Todd, a role that ultimately went to Sasha Alexander. " I think Jennifer Aniston was available at the time,...