Millennials of a certain vintage may know “Deli Boys” creator Abdullah Saeed from his cannabis-related content for Vice, including shows like “Weediquette” and “Bong Appetit.” With his new Hulu sitcom, Saeed has both made the switch to scripted series and upgraded to harder stuff. The namesake protagonists of “Deli Boys,” two spoiled rich kids who suddenly lose their father, are stunned to learn their family legacy isn’t actually a regional chain of Delaware Valley convenience stores: It’s the cocaine smuggling ring for which the delis were just a distribution front.

A crime comedy with a heavy skew toward the comedy, “Deli Boys” sets its unserious tone with the slapstick demise of patriarch Baba Dar (Iqbal Theba), who gushes blood after taking a golf ball to the head as his slack-jawed failsons Mir (Asif Ali) and Raj (Saagar Shaikh) look on in horror. Mir and Raj are a classic odd couple,...