Chelsea Handler opens her new special, The Feeling, by thanking the “homosexual” fans who’ve gotten her where she is today — particularly the gay men, whom she gives a special shout-out for their part in having gotten vaccinated against monkeypox a few years ago so that straight people “never had to deal with” an epidemic. Handler goes on to share useful public health information about how the disease is spread: anal penetration is the main one, so the CDC said you should “avoid” it, “as if it just sneaks up on you at the bank,” Handler jokes. But she also lets straight audience members know that anal penetration is “trending,” and advises anyone thinking of trying it out for the first time, “You have to pick a medium to small male. Can’t do that with 50 Cent. No. Jo Koy, maybe, but not 50 Cent.”

That’s the thing about a...