Andrew Karpen, founder and CEO of Bleecker Street, has died after an extended battle with glioblastoma, a form of brain cancer. He was 59.

Karpen was a mainstay of the independent film industry for much of the 21st century, serving as co-ceo of Focus Features for more than a decade before leaving to found Bleecker Street, which took its name from the New York street where Focus’ headquarters was located, in 2014.

Bleecker Street made its first film acquisition at TIFF 2014 with “Pawn Sacrifice,” which starred Tobey Maguire as chess legend Bobby Fischer. In the decade since, Bleecker Street’s filmography has included movies like “Captain Fantastic” starring Viggo Mortensen and “Trumbo” starring Bryan Cranston, both of whom received Oscar nominations for their performances.

Other films include the Steven Soderbergh heist film “Logan Lucky” and the war drama “Eye in the Sky” starring Helen Mirren as well as Alan Rickman in his last live action role.