Michael Scofield (Wentworth Miller) has a special gift. During the five seasons "Prison Break" was on the air, he showed that there wasn't a single penitentiary on the planet he couldn't break in or out of. Granted, he didn't visit every prison in the world, but the show establishes that he knows how to get out of any sticky situation, so why should we believe that there are any cells that could keep him locked up? For viewers, Michael's escapades provided some edge-of-the-seat entertainment, even when the series started getting ridiculous and running out of steam.

Then again, prison wasn't the only problem Michael had to contend with on "Prison Break." At one point, he suffers from a brain tumor that puts his life in danger, requiring him to get an experimental treatment. However, his problems further intensify when he enters into business with some bad people and gets caught up in an explosion.