Aside from the physical difficulties Christina Applegate faces as someone with multiple sclerosis, the “Dead to Me” actress revealed she also has to deal with unkind speculation about how she might have contracted the degenerative disease — in addition to bizarre “cure” suggestions.

Applegate, along with fellow Ms sufferer and acrtess Jamie-Lynn Sigler, joined Conan O’Brien on Monday’s episode of his “Conan O’Brien Needs a Friend” podcast via video.

“I think that the first thing that I hear from people is, ‘How did you get it?'” she told O’Brien. “Meaning, I must have done something wrong in my life to have this disease. I did it to myself. I had breast cancer as well. So, ‘Oh, you must have done something.'”

She continued, noting that she is “used to” the stigma now. “But for a while it was so hard to swallow because, why the F would...