To quote Nick Kroll’s Maury, “It’s the end of a very gross era.” “Big Mouth” dropped the trailer for its eighth and final season on Wednesday, and it’s just as upsetting and surprisingly sweet as this raunchy animated comedy has always been. The longest-running scripted Netflix original will premiere on May 23.

“Do you schmucks even know why you go through puberty?” Natasha Lyonne asks as a sassy new teacher. The video then cuts to a series of embarrassing scenes, from Missy (Ayo Edebiri) accidentally farting on another student’s lunch to Jessi (Jessi Klein) panicking about her Pms. But it’s not all humiliating bodily functions. The trailer also shows Lola (Kroll) introducing Matthew (Andrew Rannells) to something called the gay pornscape, a colorful land filled with men happily exploring their various kinks. And this season has a special surprise in store for one of its main...