Mark Ruffalo (Poor Things) and Tucker Pillsbury (aka Role Model) are set to star alongside Natalie Portman in Good Sex, writer-director Lena Dunham’s new romantic comedy for Netflix.

The film centers on pragmatic couples’ therapist Ally, who after spending a decade in a failed relationship, is turning 40 and reluctantly dipping her toe back into the New York dating scene. But she gets more than she bargained for when she meets two men — one in his twenties and one in his fifties — who show her there is no set formula for good sex.

Portman and Sophie Mas are producing for MountainA, alongside Dunham and Michael Cohen for Good Thing Going Productions. Tim Bevan and Michael Sledd are exec producing, along with Michaela Celella for MountainA.

Good Sex is one of two rom-com projects Dunham has coming to Netflix, the other being series Too Much, starring Will Sharpe and Megan Stalter,...