“Lilo & Stitch” is successfully causing box office mayhem. Disney’s latest live-action remake ignited to $341 million globally, including a mighty $157.8 million from international markets.

It’s the second-largest worldwide opening weekend of the year behind the Warner Bros. video game adaptation “A Minecraft Movie” ($313 million worldwide over three days). Ticket sales for “Lilo” also rank as the third-best start for Disney’s live-action reboots following 2019’s “The Lion King” and 2017’s “Beauty and the Beast,” which each ended up grossing over $1 billion.

With great word-of-mouth and generation-spanning appeal, “Lilo & Stitch” could reach similar box office heights. Dean Fleischer Camp directed the reboot about a chaotic alien who crash-lands in Hawaii and gets adapted by a young girl and her older sister. Top earning territories are Mexico with $23.7 million to start, the United Kingdom with $12.9 million and Brazil with $11.1 million.

This weekend’s other newcomer, Paramount and Skydance’s...