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- Journalist Stone Phillips interviews the creators and current cast members of the series ER.
- Actor Ben Affleck talks about his latest film, "Jersey Girl"; Liza Minnelli and Lorna Luft discuss their mother, Judy Garland; rape allegations involving U.S. military personnel; three teenagers attend a weight-loss camp.
- Did one of the nation's largest pharmaceutical companies put patients at risk by touting the drug Neurontin for unapproved uses? The episode reveals the results of a yearlong Dateline investigation. Exclusive interviews with whistle blower David Franklin and attorney Thomas Greene.
- Dateline goes in depth on America's fascination with hollywood celebrity Tom Cruise on the weekend of the opening of Mission Impossible 3.