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The Powers had tried to make improvements to their fixer-upper home, but when youngest daughter Olivia was diagnosed with a life-threatening form of leukemia, caring for her became a family affair and took time away from working on the house. Now cured, Olivia got through her cancer treatment with the loving support of family and friends, including a special mural in the house her mother painted.

When Trent Woslum, a sergeant in the California National Guard, was finally able to buy his family their first fixer-upper home as a Christmas present in 2002, little did he know that by Valentine's Day he would have to leave the house, his wife and three sons behind to serve a tour of duty in Iraq. The mission facing the "EM: HE" team: A complete renovation of the Palmdale, California home and bring Dad home for an emotional reunion.

When the "extreme" nine-member Harris family from Birmingham, Alabama received the remarkable news that their house would get an "Extreme Makeover: Home Edition," Chris and Diamond Harris were thankful that some of the exhaustion that stems from taking care of their toddler sextuplets and nine-year-old son DeWayne would finally be relieved.

Susan Tom, a single mother who lives in Fairfield, California, lives with her seven surviving adopted children, all daughters (an eighth, a son, died of a congenital skin disorder in late 2004; she also has two grown biological children from her previous marriage). All of the adopted children have disabilities of some kind. Their current two-story home was completely unsuitable for the girls' special needs. The team built the family a new three-story home, complete with an elevator for the three girls who need wheelchairs.

For years John Cox travelled worldwide to help churches and organizations. Meanwhile, to support her dedicated husband's endeavours, his wife, Wendy, quit her job as a nurse to stay at home and care for their three young daughters. When he received a permanent position as a youth minister, John was able to buy his family their very first home. Now their humble abode in Simi Valley, California, has received a complete renovation and been transformed into a real dream house.

Shortly after Gordon Harrison, a married father of three in the Salt Lake City, Utah suburb of Bountiful, Utah, started a cabinetry business, he was diagnosed with pancreatic cancer. While in chemotherapy, he spent almost a year in a project to remake a neighbor's home. However, his health struggles and his commitment to his neighbors meant that he could not repair his house, and it was rapidly falling apart. People in his neighborhood nominated him for this makeover.

When the "extreme" nine-member Harris family from Birmingham, Alabama received the remarkable news that their house would get an "Extreme Makeover: Home Edition," Chris and Diamond Harris were thankful that some of the exhaustion that stems from taking care of their toddler sextuplets and nine-year-old son DeWayne would finally be relieved.

When a young girl was diagnosed with sun poisoning, it completely changed her life and that of her family. She is unable to go outside without first completely covering her body with a long-sleeved shirt, long pants, hat and gloves. Since the sun can also penetrate her clothing, she must apply full body sunscreen every two hours. With the combined effort from the team of designers, contractors, hundreds of workers and state-of-the-art technology, "Extreme Makeover: Home Edition" created a new living space that will enhance the quality of her life while making her living conditions much less restrictive.

A courageous mother has helped three of her adopted children and many others face AIDS with hope, teaching them that life is here for the living. Her recent bout with cancer has only enforced that belief. In this episode, the Broadbent family from North Las Vegas will get back some of the love and happiness that they have provided to so many others over the years through their tireless work providing HIV/AIDS awareness.