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The premiere episode of Conan's Tonight Show opens with Conan running all the way from New York to L.A. Later, Conan takes a Universal Studios tram tour. Also, Conan steals the "D" from the Hollywood sign, and drives through Hollywood in his Ford Taurus. Finally, Will Ferrell is interviewed, and Pearl Jam performs.

Conan's Tabloid Moment features Conan driving drunk and running over a Bible salesman. A remote segment involves Conan visiting Foley Stage and making sound effects for a Law and Order: SVU episode. Gwyneth Paltrow and Joel McHale are interviewed; John Mayer Trio performs.

Eddie Murphy/Angela Kinsey/Bonnie Raitt and Taj Mahal.

Larry David/Lauren Conrad/Gavin Rossdale.