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CO CDR Tom Chandler and his crew find themselves in a whole new world when the ship's scientist passenger, Dr. Rachel Scott, reveals that the entire planet is in their hands.

With a potential cure in their grasp, Dr. Scott asks for human volunteer's to test her formula that was successful on a monkey. However, will this be the answer she is looking for, or will it put the volunteers' lives in jeopardy?

Chandler and his crew head to the U. S. Military base at Guantanamo Bay in hopes of collecting food, medical supplies and fuel replenishments.

The James faces off against a new foe who demands Chandler hand over Rachel and her research.

Mechanical problems leave the ship with a severe shortage of drinking water.

With Rachel close to a breakthrough on her vaccine, she, Chandler and XO Slattery lead a small team into the jungles of Nicaragua on a mission to find monkeys for her vaccine trials.

With monkeys for testing, they work towards a vaccine but with no cure in sight, a serious lack of monkeys and increasingly depressing distress calls, they think about returning to Nicaragua.

With Chandler and Tex held prisoner on the Russian ship, it is up to Slattery to devise a plot to free them.

The crew of the USS Nathan James arrive in Baltimore with the cure expecting a welcoming committee, but what they find is something else entirely.

Chandler and his fractured team join forces with an underground resistance in an attempt to defeat Amy Granderson; Rachael tries to help the sick while remaining a prisoner; Sidney and the crew try to regain control of their ship.

After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leaves Chandler and Tex stranded at sea.

Slattery and the crew of Nathan James are in a race against time to save an injured Dr. Tophet and regain control of their ship.

The ship goes to Norfolk so that the crew can check on their families. And Chandler gives them the opportunity to decide if they want to continue or remain. Something even he is considering.

The crew makes a discovery; Chandler sees an opportunity to add another ship to the fleet.

Chandler and his crew face off against a nuclear-powered submarine led by British naval officers.

Chandler tracks the immunes to Northern Florida; Rachel comes across a secret formula.

As small Immune factions continue to fight the cure, CDR Chandler, and his team, put a call out to civilians to meet them at ports all over the United States to receive the cure.

Slattery struggles to evade the sub; Chandler and the land team infiltrate the immune compound.

Trying to piece together Dr. Hunter's lost formula, Rachel grapples with the fact Niels, her sworn enemy, is on board Nathan James, while Chandler works to gain intel and reverse the brainwashing Michener suffered at the hands of the Ramseys.

Chandler and his team set out to find supplies and materials for Dr. Scott's lab, only to tangle with bounty hunters and the Immunes. Meanwhile, Rachel's effort to find a spreadable cure depends on the scientist who nearly erased mankind.

Rachel is hard at work on a new, more efficient version of the cure while Alisha decodes a message found on a cell phone recovered from the Immunes on land.

Sean Ramsey broadcasts a message implicating the Navy in a devastating disaster.

The Nathan James is trapped between the sub and the civilian blockades set up by the immune. Chandler sends Dr. Scott off the ship under Slattery's protection.

Chandler scrambles to find answers in an Asian Dodge City. Meanwhile, Slattery seeks the truth about his predicament.

Chandler is sent to Asia to probe a possible mutation of the Red Flu. Captain Slattery and his crew deliver a cure to Southeast Asia but they might be heading toward an unforeseen threat.