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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- A father recounts to his children the journey he and his four best friends took leading up to him meeting their mother.
- Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.
- A team of Crime Scene Investigators (CSI's) work with the Las Vegas Police Department (LVPD) to solve crimes by using advanced scientific methods and technology.
- A low-level Cabinet member becomes President of the United States after a catastrophic attack kills everyone above him in the line of succession.
- The adventures of Superman's cousin and her own superhero career.
- A New Jersey guy dedicated to his family, friends, and church, develops unrealistic expectations from watching porn and works to find happiness and intimacy with his potential true love.
- Erik and Cooze start college and pledge the Beta House fraternity, presided over by none other than legendary Dwight Stifler.
- Freshman Rusty Cartwright arrives at college and decides he no longer wants to be the boring geek from high school. He decides to pledge a fraternity. He is offered 2 bids; one from his sister's boyfriend Evan's fraternity and one from Cappie, his sister's ex-boyfriend's fraternity. Rusty must learn to handle his new life, and his new relationship with his sister. His sister must decide if she loves Evan who is stable or Cappie who really loves her.
- A family of archeologists hunt down artifacts from fairy tales that have been hidden around the globe.
- After an experimental gene therapy turns them into monsters, three twenty-somethings band together to hunt down the scientist responsible and force him to make them human again.
- Friends gather at a wedding, but the celebration's shattered by terrifying apocalyptic events, which force them to re-examine life, choices they've made...
- April Carver, whose world has just started to look up, is diagnosed with leukemia. With the support of her family and best friend, she might just be able to fight it.
- Impressed by her no-nonsense style as she sells sandwiches outside his offices, fashion executive Max impulsively offers teenager True Jackson a dream job as vice president in charge of his youth apparel line.
- Extra, a television news updates show on current events in the mass-entertainment business such as movies, TV, music, etc.
- Two players compete against each other in a race against the clock to test their knowledge of songs performed by a live band.
- A failing racewalking coach joins forces with a former baseball pro who shows natural walking talent as they challenge the sport's top competitor.
- Revival of the classic game show, hosted by Michael Strahan. With the help of their game partners, contestants paired with celebrities must guess words or phrases that appear on the show's pyramid-shaped gameboard to win money.
- When a struggling musician moves back into her childhood home, she discovers a recording of her deceased father confessing to a grisly murder he claims to have committed to protect himself from an unknown evil force. As her young son exhibits increasingly unsettling behavior, she becomes more and more desperate in her attempts to stop the evil.
- Show will focus on home improvements, crafts, parenting tips, and lifestyle, health and fitness enhancements.
- A team of medical professionals discuss a range of various health-related topics and answer questions from viewers who are too embarrassed to ask their own doctors.
- Miranda runs a boot camp for the recently brokenhearted. She begins to form a connection with new client Ben--who is also a reporter, investigating whether her boot camp is a scam or a phenomenon.
- A remake of "Roman Holiday" will be filmed in Rome and an unknown woman is chosen to play the lead. Once in Rome, she meets a reporter/porter/waiter/aspiring novelist, who gets the exclusive story on her. Roman romance?
- A young man is sent to live with his uncle and cousin in Washington DC by his anthropologist parents. In the process, he must use the skills he learned around the world in order to solve various crimes and conspiracies.
- Michelle (Ricci) is the dreamer of her family, always brimming with imaginative ideas to make the world a better place. This Christmas, her sister Keri desperately needs a new home, and Michelle hatches a creative plan to help. Starting with just a Christmas stocking, she sets out to trade her way up to something far greater-a house for Keri. While Keri dismisses it as a far-fetched idea, local reporter Dan (Xavier) is intrigued. Assigned to cover Michelle's story, Dan follows her closely, and as her plan gains attention, he starts to see the world through her hopeful eyes. As Michelle and Dan grow closer, so do their feelings for each other. But when it seems her plan has failed and she fears ruined her relationship with Keri, Michelle is ready to give up. It's Dan's love and belief in her that reignites hope just when she needs it most.