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Sheriff John Henry Hoyle and his reluctant Deputy Eli introduce the emerging science of forensics to an 1875 Kansas town.

Real-estate mogul Christopher Gates becomes homeless after losing his family, only to discover the sinister connection to their deaths.

Hoyle, Eli and Shank return to Nicodemus, a town populated entirely by freed slaves, to sell off Eli's cattle. When the cattle drive doesn't go as expected, Hoyle enters Eli in a rodeo to win the cash.