Ex-MI6 agent Russ Taylor recruits former Phoenix Foundation members Mac, Riley, Bozer, Matty and Desi to hunt down a bio-weapon that's planned to be used by a mysterious organization for a devastating attack on a major U.S. city.
A general gives Phoenix a chance to regain its security clearance by testing a military lab's security, stealing a chip there. Things don't go as planned.
As MacGyver works quickly to rescue survivors from a collapsed building in Germany, he discovers a new safety threat - an undetonated bomb from World War II hidden beneath the rubble.
In an attempt to find the main players in the Codex and cut off their match-fixing funding, Desi goes undercover to infiltrate a soccer team and find the corrupt player working with the shadow organization.
When Russ's former love, Emilia, is kidnapped by the same rebels he fought during the military contract days, he takes the Phoenix team to a small, impoverished town to rescue her and rid the town of the rebels for good.
The Phoenix team is forever altered when MacGyver's Aunt Gwen gets into his head about family and connection and convinces Mac and Riley to join Codex. Also, Matty and Russ take their concerns about Codex to the White House.
A double date descends into chaos when Mac and Desi witness a murder in the back of the restaurant, and as they work to find the killer, Riley tries to keep the secret about about their "day jobs" from her boyfriend, Aubrey
Los Angeles' power grid is taken hostage in a ransomware attack resulting in a citywide blackout; the team discovers that the ransomware code used was written by Riley years ago.
When Mac is put into a dream state to help him recall key evidence found in Nikola Tesla's secret lab that could stop Codex's deadly plot, he encounters Nikola Tesla, Alexander Graham Bell, Thomas Edison...and his mother.
Matty splits the team up for a mission, and partners the teammates with their fellow teammates they had the most problems with during the Codex affair.
After spending five years in a cave in Pakistan being a kidnapped victim of a terrorist group, Angus MacGyver is recruited by Phoenix Foundation to solve life-threatening problems.
When Taylor's former protégé is killed while preventing a bio-weapon from falling into the wrong hands, Mac and the team must find the weapon so Desi can pull off the ultimate heist before it's sold to a terrorist cell.
When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues.
Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped.
During COVID-19's first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor's house.
The secret experimental cancer treatment Mac's developing with a friend is discovered when culprits ransack their lab, kidnap Mac's partner and plan to use the research to create a powerful new nerve agent.
Mac and team rush to help when Matty's former mentor, Ian Cain, and his embassy staff come down with a deadly, mysterious illness. Also, Taylor and Bozer work with Jerry Ortega.
When Mac and the team are unable to prevent Department of Defense intel from falling into Codex's hands, Mac must scale a vertical cliff using only gear he can cobble together himself to prevent the info's transmission
